Kazan medical journalKazan medical journal0368-48142587-9359Eco-Vector150910.17816/KMJ1509Research ArticleImproving the local treatment effect in oral lichen planusRonG I-AkmalovaG Makmalova-ekb@yandex.ruUral State Medical University, Yekaterinburg, RussiaBashkir State Medical University, Ufa, Russia1506201495333834028032016Copyright © 2014, Ron G.I., Akmalova G.M.2014Aim. To assess the clinical efficacy of local use of titanium glycerosolvate aqua-complex (Tisolum) in combination with hyaluronidase as a component of the complex treatment of oral lichen planus. Methods. The study included 49 patients with typical form of oral lichen planus aged 29 to 65 years. The first group included 25 patients, who received the local treatment with glycerosolvate aqua-complex (Tisolum) in combination with hyaluronidase as a component of the complex treatment. The second group included 24 patients who were treated conventionally. Results. The patients of the treatment group reported the decrease of the oral mucosa tightness and roughness sensation 5.78±0.26 days after the treatment initiation, which was 1.5 times faster compared to the control group (8.6±0.34 days, р 0.05). On the seventh day of treatment, there was a significant papule deflorescence in 19 (76.0%) out of 25 patients of the main group, compared to 11 (45.8%) out of 24 patients of the control group (р 0.05). On the 10-th day, disappearance or downsizing of lesions without signs of active inflammation was observed in all 25 patients of the treatment group, compared to 16 (66.7%) of the control group patients (р 0.05). On the 14-th day, no mucosal lesions were observed in all 25 patients of the treatment group, which was significantly better compared to 9 (37.5%) out of 24 patients of the control group (р 0.05). Regression of clinical signs of the disease at the treatment end was registered in all patients of the main group and in 14 (58.3%) patients of the control group. Conclusion. Local use of composite gel containing titanium glycerosolvate aqua-complex (Tisolum) in combination with hyaluronidase as a component of the complex treatment of oral lichen planus is highly effective.lichen planusoral mucosatitanium glycerosolvate aqua-complex (Tisolum)hyaluronidaseкрасный плоский лишайслизистая оболочка полости ртааквакомплекс титана глицеросольвата (тизоль)гиалуронидаза (лидаза)[Лукиных Л.М., Тиунова Н.В. Оптимизация лечения красного плоского лишая слизистой оболочки полости рта // Маэстро стоматологии. - 2009. - №4. - С. 79-81.][Петрова Л.В. Эльтеанс в комплексной терапии различных клинических форм плоского лишая слизистой оболочки полости рта // Вестн. дерматол. и венерол. - 2004. - №2. - С. 66-67.][Самойлова О.П., Молоков В.Д., Носков С.И. и др. Оценка эффективности местного лечения больных женщин с эрозивно-язвенной формой красного плоского лишая, ассоциированного с йоддефицитным состоянием // Сиб. мед. ж. - 2007. - №5. - С. 44-46.][Dalirsani Z., Zenouz A.T., Mehdipour M. et al. Comparison of the effect of combination of triamcinolone acetonide and vitamin A mouthwash with triamcinolone mouthwash alone on oral lichen planus // J. Dent. Res. Dent. Clin. Dent. Prospect. - 2010. - Vol. 4. - P. 21-24.][Mehdipour M., Zenouz A.T., Bahramian A. et al. Comparison of the effect of mouthwashes with and without zinc and fluocinolone on the healing process of erosive oral lichen planus // J. Dent. Res. Dent. Clin. Dent. Prospect. - 2010. - Vol. 4. - P. 25-28.][Petruzzi M., De Benedittis M., Grassi R. et al. Oral lichen planus: a preliminary clinical study on treatment with tazarotene // Oral Dis. - 2002. - Vol. 8. - P. 291-295.][Swift J.C., Rees T.D., Plemons J.M. et al. The effectiveness of 1% pimecrolimus cream in the treatment of oral erosive lichen planus // J. Periodontol. - 2005. - Vol. 76. - P. 627-635.]