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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Kazan medical journal</journal-id><journal-title-group><journal-title xml:lang="en">Kazan medical journal</journal-title><trans-title-group xml:lang="ru"><trans-title>Казанский медицинский журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0368-4814</issn><issn publication-format="electronic">2587-9359</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">106316</article-id><article-id pub-id-type="doi">10.17816/KMJ2022-650</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Reviews</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Обзоры</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">The link of smoke and solar activity with human neoplasms</article-title><trans-title-group xml:lang="ru"><trans-title>Связь дыма и солнечной активности с новообразованиями человека</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0774-2376</contrib-id><contrib-id contrib-id-type="scopus">56291097200</contrib-id><contrib-id contrib-id-type="researcherid">J-5942-2018</contrib-id><name-alternatives><name xml:lang="en"><surname>Pinaev</surname><given-names>Sergey K.</given-names></name><name xml:lang="ru"><surname>Пинаев</surname><given-names>Сергей Константинович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>M.D., Cand. Sci. (Med.), Assoc. Prof., Depart. of Oncology with a course of surgery and endoscopy of additional postgraduate education</p></bio><bio xml:lang="ru"><p>канд. мед. наук, доц., каф. онкологии с курсом хирургии и эндоскопии ДПО</p></bio><email>pinaev@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0542-1552</contrib-id><contrib-id contrib-id-type="scopus">57205541090</contrib-id><contrib-id contrib-id-type="researcherid">L-6981-2016</contrib-id><contrib-id contrib-id-type="spin">6701-2688</contrib-id><name-alternatives><name xml:lang="en"><surname>Chizhov</surname><given-names>Alexey Ya.</given-names></name><name xml:lang="ru"><surname>Чижов</surname><given-names>Алексей Ярославович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>M.D., D. Sci. (Med.), Prof., Depart. of Human Ecology and Bioelementology, Institute of Ecology</p></bio><bio xml:lang="ru"><p>докт. мед. наук, проф., заслуженный деятель науки РФ, академик Российской экологической академии, профессор-консультант департамента «Экологии человека и биоэлементологии», Институт экологии</p></bio><email>ma21@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9676-845X</contrib-id><contrib-id contrib-id-type="scopus">56290752700</contrib-id><contrib-id contrib-id-type="researcherid">AAC-3445-2020</contrib-id><contrib-id contrib-id-type="spin">1678-3743</contrib-id><name-alternatives><name xml:lang="en"><surname>Pinaeva</surname><given-names>Olga G.</given-names></name><name xml:lang="ru"><surname>Пинаева</surname><given-names>Ольга Геннадьевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>M.D., Cand. Sci. (Med.), Assoc. Prof., Depart. of Normal and Pathological Physiology</p></bio><bio xml:lang="ru"><p>канд. мед. наук, доц., каф. нормальной и патологической физиологии</p></bio><email>pinaeva_og@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Far Eastern State Medical University</institution></aff><aff><institution xml:lang="ru">Дальневосточный государственный медицинский университет</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Peoples' Friendship University of Russia</institution></aff><aff><institution xml:lang="ru">Российский университет дружбы народов</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2022-08-15" publication-format="electronic"><day>15</day><month>08</month><year>2022</year></pub-date><volume>103</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>650</fpage><lpage>657</lpage><history><date date-type="received" iso-8601-date="2022-04-16"><day>16</day><month>04</month><year>2022</year></date><date date-type="accepted" iso-8601-date="2022-06-14"><day>14</day><month>06</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2022, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2022, Эко-Вектор</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2025-08-15"/></permissions><self-uri xlink:href="https://kazanmedjournal.ru/kazanmedj/article/view/106316">https://kazanmedjournal.ru/kazanmedj/article/view/106316</self-uri><abstract xml:lang="en"><p>A review of the literature on the link of various types of smoke and solar activity with human neoplasms is presented. The significance of benign and malignant neoplasms in young children aged 0–4 years as an indicator of carcinogenic effects on the population is shown. Information about the oncogenic potential of all types of smoke, including exhaust gases, tobacco smoke and smoke from forest fires is provided. The special danger of vehicle exhaust gases is indicated in connection with the content of benzene, which is a proven human carcinogen. There is extensive evidence linking various types of smoke with the development of leukemia, Hodgkin's lymphoma, non-Hodgkin's lymphomas, multiple myeloma, retinoblastoma, neuroblastoma, hepatoblastoma, hemangiomas, and tumors of the central nervous system. Data on the connection between solar activity, in particular ultraviolet radiation, and the risk of leukemia, lymphomas as well as such neoplasms in young children aged 0–4 years as nephroblastoma, hemangioma, benign tumors and soft tissue sarcomas are highlighted. The possible role of geomagnetic field fluctuations in the genesis of hemoblastoses in children and adults is considered. The importance of ecologically determined oxidative stress in the realization of the oncogenic potential of environmental factors is shown. Possible measures for the prevention of neoplasms by reducing the intensity of human exposure to environmental factors, as well as methods for stopping oxidative stress, are considered. Recommendations on increasing the effectiveness of antioxidant protection by stimulating autophagy through the introducing various plant components, alkylcatechols into the diet, and correcting immunodeficiency with transfer factor are given.</p></abstract><trans-abstract xml:lang="ru"><p>Представлен обзор литературы о связи различных видов дыма и солнечной активности с новообразованиями человека. Показано значение доброкачественных и злокачественных новообразований у детей младшего возраста 0–4 лет в качестве индикатора канцерогенного воздействия на популяцию. Приведены сведения об онкогенном потенциале всех видов дыма, включая выхлопные газы, табачный дым и дым лесных пожаров. Указано на особую опасность выхлопных газов транспортных средств в связи с содержанием в них бензола — доказанного канцерогена для человека. Представлены обширные свидетельства связи различных видов дыма с развитием лейкоза, лимфомы Ходжкина, неходжкинских лимфом, множественной миеломы, ретинобластомы, нейробластомы, гепатобластомы, гемангиом и опухолей центральной нервной системы. Освещены данные о связи активности Солнца, в частности ультрафиолетового излучения, с риском возникновения лейкоза, лимфом, а также таких новообразований у детей младшего возраста 0–4 лет, как нефробластома, гемангиома, доброкачественные опухоли и саркомы мягких тканей. Рассмотрена возможная роль колебаний геомагнитного поля в генезе гемобластозов у детей и взрослых. Показано значение экологически обусловленного окислительного стресса в реализации онкогенного потенциала факторов внешней среды. Рассмотрены возможные меры профилактики новообразований путём снижения интенсивности воздействия на человека экологических факторов, а также методы купирования окислительного стресса. Даны рекомендации по повышению эффективности антиоксидантной защиты путём стимуляции аутофагии с помощью введения в рацион различных растительных компонентов, алкилкатехолов и коррекции иммунодефицита препаратами трансфер фактора.</p></trans-abstract><kwd-group xml:lang="en"><kwd>smoke</kwd><kwd>exhaust gases</kwd><kwd>forest fires</kwd><kwd>solar activity</kwd><kwd>neoplasms</kwd><kwd>tumors</kwd><kwd>review</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>дым</kwd><kwd>выхлопные газы</kwd><kwd>лесные пожары</kwd><kwd>солнечная активность</kwd><kwd>новообразования</kwd><kwd>опухоли</kwd><kwd>обзор</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Pinaev SK, Chizhov AYa, Pinaeva OG. Critical periods of adaptation to smoke and solar activity in human ontogenesis: a review. Ekologiya cheloveka. 2021;(11):4–11. (In Russ.) 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