Kazan medical journalKazan medical journal0368-48142587-9359Eco-Vector1050610.17816/KMJ2018-919Research ArticleFeatures of antioxidant system in patients with obstructive jaundice of benign and malignant origin in dynamicsElmanovaN Gelm-nina@yandex.ruMedical Research Institute for Northern Problems2511201899691992326112018Copyright © 2018, Elmanova N.G.2018<p><strong>Aim.</strong> Study of the features of changes of antioxidant protection in patients with mechanical jaundice of benign and malignant origin in dynamics.</p>
<p><strong>Methods.</strong> The author studied the role of antioxidant system in the progression of mechanical jaundice of various origins in 104 patients. Groups of patients with a syndrome of mechanical jaundice of benign (62 patients) and malignant origin (42 patients) were isolated. The material of the study was blood from the ulnar vein, which was taken in the morning on an empty stomach before surgery. In the dynamics (on the 7th day after the operation), 53 patients were examined. To assess the state of antioxidant protection, a spectrophotometric method of investigation was used.</p>
<p><strong>Results.</strong> A high level of malonic dialdehyde, the product of lipid peroxidation, was determined in all patients regardless of origin. There was also a depression of the enzymatic link of antioxidant protection (a decrease in the activity of superoxide dismutase and catalase). After surgical intervention in patients with mechanical jaundice of benign origin, correction of the level of reduced glutathione was observed. In patients with mechanical jaundice of malignant origin in dynamics, the activity of antioxidant enzymes did not differ significantly from the norm (p1-3 = 0,23; p1-3 = 311).</p>
<p><strong>Conclusion.</strong> After surgical intervention, partial improvement of the condition of patients with mechanical jaundice of benign origin was observed, and dysfunction of antioxidant protection persisted in patients with mechanical jaundice of malignant origin.</p>mechanical jaundicelipid peroxidationantioxidant systemcholelithiasisмеханическая желтухаперекисное окисление липидовантиоксидантная системажелчнокаменная болезнь[Gracanin A.G., Kujundzić M., Petrovecki M., et al. Etiology and epidemiology of obstructive jaundice in Continental Croatia. Coll. Antropol. 2013; 37 (1): 131–133. PMID: 23697262.][Smirnova O.V., Tsukanov V.V., Sinyakov A.A. Patterns of changes in pro-oxidant and antioxidant systems in blood plasma for chronic gastritis, chronic atrophic gastritis and gastric cancer. Helicobacter. 2017; 51 (22): 74–75. DOI: 10.1111/hel.12416.][Smirnova O.V., Titova N.M., Elmanova N.G. The relationship between the pro-oxidant and antioxidant system status of patients with multiple myeloma and the disease stage. Byulleten' eksperimental'noy biologii i meditsiny. 2014; 157 (3): 375–379. (In Russ.)][Smirnova O.V., Titova N.M., Elmanova N.G. The role of the prooxidant system in the progression of myeloma. Vrach-aspirant. 2013; 60 (5.1): 152–157. (In Russ.)][Danilov M.V., Glabay V.P., Kustov A.E., et al. Surgical treatment of patients with mechanical jaundice of tumor etiology. Annaly khirurgicheskoy gepatologii. 1997; 2: 110–116. (In Russ.)][Belyaev A.N., Khvostunov S.I., Belyaev S.A., Kostin S.V. Metabolic correction of cerebral disorders in obstructive cholestasis (experimental study). Annaly khirurgicheskoy gepatologii. 2016; 21 (2): 86–91. (In Russ.)][Kharnas S.S., Sinitsin V.E., Shekhter A.I. Diagnostic approach to mechanical jaundice, complicated by purulent cholangitis. Khirurgiya. 2003; 6: 36–41. (In Russ.)][Khokonov M.A., Silina E.V., Stupin V.A., Gakhramanov N.V., Bolevich S.B., Menshova N.I., Sinelnikova T.G., Balkizov Z.Z. Free radical processes in patients with acute calculous cholecystitis. Khirurgiya. Zhurnal im. N.I. Pirogova. 2011; 2: 58–64. (In Russ.)][Sinyakov A.A., Smirnova O.V., Darenskaya M.A., Titova N.M. State of the system of lipid peroxidation — antioxidant protection in men with chronic atrophic gastritis against the background of Helicobacter pylori infection. Rossiyskiy allergologicheskiy zhurnal. 2018; 15 (1–2): 100–103. (In Russ.)][Tsukanov V.V., Smirnova O.V., Kasparov E.V., Sinyakov A.A., Vasyutin A.V., Tonkikh Yu.L. Changes in pro-oxidant and antioxidant systems in blood plasma in men with atrophic gastritis and stomach cancer. Terapevticheskiy arkhiv. 2018; 90 (2): 24–27. (In Russ.)][Smirnova O.V., Manchouk V.T., Savchenko A.A. Immune status & enzymes activity in blood lymphocytes in adult patients at different stages of acute lymphoblastic leukaemia. Indian J. Med. Res. 2011; 133 (3): 280–286. PMID: 21441681.]