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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Kazan medical journal</journal-id><journal-title-group><journal-title xml:lang="en">Kazan medical journal</journal-title><trans-title-group xml:lang="ru"><trans-title>Казанский медицинский журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0368-4814</issn><issn publication-format="electronic">2587-9359</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">100990</article-id><article-id pub-id-type="doi">10.17816/kazmj100990</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>New methods and rationalization proposals</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Новые методы и рационализаторские предложения</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Method for the determination of phosphabenzide in biological fluids</article-title><trans-title-group xml:lang="ru"><trans-title>Метод определения фосфабензида в биологических жидкостях</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Valimukhametova</surname><given-names>D. A.</given-names></name><name xml:lang="ru"><surname>Валимухаметова</surname><given-names>Д. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Clinical Pharmacology and Internal Medicine No. 3, Department of Analytical Chemistry</p></bio><bio xml:lang="ru"><p>Кафедра клинической фармакологии и внутренних болезней № 3, кафедра аналитической химии</p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Pogoreltsev</surname><given-names>V. I.</given-names></name><name xml:lang="ru"><surname>Погорельцев</surname><given-names>В. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Clinical Pharmacology and Internal Medicine No. 3, Department of Analytical Chemistry</p></bio><bio xml:lang="ru"><p>Кафедра клинической фармакологии и внутренних болезней № 3, кафедра аналитической химии</p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Harmonov</surname><given-names>S. Yu.</given-names></name><name xml:lang="ru"><surname>Гармонов</surname><given-names>С. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Clinical Pharmacology and Internal Medicine No. 3, Department of Analytical Chemistry</p></bio><bio xml:lang="ru"><p>Кафедра клинической фармакологии и внутренних болезней № 3, кафедра аналитической химии</p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Trubnikova</surname><given-names>G. G.</given-names></name><name xml:lang="ru"><surname>Трубникова</surname><given-names>Г. Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Clinical Pharmacology and Internal Medicine No. 3, Department of Analytical Chemistry</p></bio><bio xml:lang="ru"><p>Кафедра клинической фармакологии и внутренних болезней № 3, кафедра аналитической химии</p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Bagautdinova</surname><given-names>D. B.</given-names></name><name xml:lang="ru"><surname>Багаутдинова</surname><given-names>Д. Б.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Clinical Pharmacology and Internal Medicine No. 3, Department of Analytical Chemistry</p></bio><bio xml:lang="ru"><p>Кафедра клинической фармакологии и внутренних болезней № 3, кафедра аналитической химии</p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Budnikov</surname><given-names>G. K.</given-names></name><name xml:lang="ru"><surname>Будников</surname><given-names>Г. К.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Clinical Pharmacology and Internal Medicine No. 3, Department of Analytical Chemistry</p></bio><bio xml:lang="ru"><p>Кафедра клинической фармакологии и внутренних болезней № 3, кафедра аналитической химии</p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Evgeniev</surname><given-names>M. I.</given-names></name><name xml:lang="ru"><surname>Евгеньев</surname><given-names>М. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Clinical Pharmacology and Internal Medicine No. 3, Department of Analytical Chemistry</p></bio><bio xml:lang="ru"><p>Кафедра клинической фармакологии и внутренних болезней № 3, кафедра аналитической химии</p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Kazan Medical University</institution></aff><aff><institution xml:lang="ru">Казанский медицинский университет</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Kazan Technological University</institution></aff><aff><institution xml:lang="ru">Казанский технологический университет</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="1995-05-15" publication-format="electronic"><day>15</day><month>05</month><year>1995</year></pub-date><volume>76</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>263</fpage><lpage>265</lpage><history><date date-type="received" iso-8601-date="2022-02-17"><day>17</day><month>02</month><year>2022</year></date><date date-type="accepted" iso-8601-date="2022-02-17"><day>17</day><month>02</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 1995, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 1995, Эко-Вектор</copyright-statement><copyright-year>1995</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://kazanmedjournal.ru/kazanmedj/article/view/100990">https://kazanmedjournal.ru/kazanmedj/article/view/100990</self-uri><abstract xml:lang="en"><p>Individual pharmacokinetic characteristics of drugs in most cases are due to differences in their absorption, distribution, metabolism and excretion. In some cases, the conclusion about the inefficiency of the drug is a consequence of the inadequacy of the dosing regimen, which is due, in turn, to the lack of a method for the quantitative determination of the drug in biological media of the whole organism.</p></abstract><trans-abstract xml:lang="ru"><p>Индивидуальные фармакокинетические особенности лекарственных средств в большинстве случаев обусловлены различиями в их всасывании, распределении, метаболизме и экскреции. В ряде случаев заключение о неэффективности препарата является следствием неадекватности схемы его дозирования, что обусловлено, в свою очередь, отсутствием метода количественного определения лекарственного препарата в биологических средах целостного организма.</p></trans-abstract><kwd-group xml:lang="en"><kwd>Kazan Medical archive</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>Казанский медицинский архив</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Евгеньев М. И., Евгеньева И. И., Николаева Н. Г. и др.//Хим.-фарм. журн.—1991.— № 10, —С. 80</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Евгеньев М. И. и др. А. с. 171812 (СССР). Б. И.— 1992.— № 9</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Заиконникова И. В., Вальдман А. В., Козловская М. М. и др.//Фармакол. и токсикол. — 1980.— № 4.— С. 6</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Луйк А. И., Лукъянчук В. Д. Сывороточный альбумин и биотранспорт ядов. — М., 1971</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Методы экспериментальной химиотерапии./Под ред. Г. Н. Першина.— М., 1971</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Пинягина К. В., Литвиненко А. В., Тарасова Р. И. и др.//Фармация, — 1992, — № 1. — с. 31—35</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Рыбакова Л. С., Семенова Л. А. Научн. тр. Казанского мед. ин-та.— Казань, 1974. — T. I.— Вып. 2.— С. 127—131</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Холодов Л. А., Яковлев В. П. Клиническая фармакокинетика. — М., 1985</mixed-citation></ref></ref-list></back></article>
