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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Kazan medical journal</journal-id><journal-title-group><journal-title xml:lang="en">Kazan medical journal</journal-title><trans-title-group xml:lang="ru"><trans-title>Казанский медицинский журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0368-4814</issn><issn publication-format="electronic">2587-9359</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">100637</article-id><article-id pub-id-type="doi">10.17816/kazmj100637</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Pharmacy</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Фармация</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Spray lotion «Debut» — a medicinal and cosmetic composition with dimephosphone</article-title><trans-title-group xml:lang="ru"><trans-title>Аэрозольный лосьон «Дебют» — новое лечебно-косметическое средство, содержащее димефосфон</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Egorova</surname><given-names>S. N.</given-names></name><name xml:lang="ru"><surname>Егорова</surname><given-names>С. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Pharmacology, Department of Drug Technology</p></bio><bio xml:lang="ru"><p>Кафедра фармакологии, кафедра технологии лекарств</p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Ziganshina</surname><given-names>L. E.</given-names></name><name xml:lang="ru"><surname>Зиганшина</surname><given-names>Л. Е.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Pharmacology, Department of Drug Technology</p></bio><bio xml:lang="ru"><p>Кафедра фармакологии, кафедра технологии лекарств</p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Studentsova</surname><given-names>I. A.</given-names></name><name xml:lang="ru"><surname>Студенцова</surname><given-names>И. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Pharmacology, Department of Drug Technology</p></bio><bio xml:lang="ru"><p>Кафедра фармакологии, кафедра технологии лекарств</p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Garaev</surname><given-names>R. S.</given-names></name><name xml:lang="ru"><surname>Гараев</surname><given-names>Р. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Pharmacology, Department of Drug Technology</p></bio><bio xml:lang="ru"><p>Кафедра фармакологии, кафедра технологии лекарств</p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Potselueva</surname><given-names>L. A.</given-names></name><name xml:lang="ru"><surname>Поцелуева</surname><given-names>Л. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Pharmacology, Department of Drug Technology</p></bio><bio xml:lang="ru"><p>Кафедра фармакологии, кафедра технологии лекарств</p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kadyrova</surname><given-names>E. A.</given-names></name><name xml:lang="ru"><surname>Кадырова</surname><given-names>Е. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Pharmacology, Department of Drug Technology</p></bio><bio xml:lang="ru"><p>Кафедра фармакологии, кафедра технологии лекарств</p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Vizel</surname><given-names>A. O.</given-names></name><name xml:lang="ru"><surname>Визель</surname><given-names>А. О.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Pharmacology, Department of Drug Technology</p></bio><bio xml:lang="ru"><p>Кафедра фармакологии, кафедра технологии лекарств</p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Muslunkin</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Муслинкин</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Pharmacology, Department of Drug Technology</p></bio><bio xml:lang="ru"><p>Кафедра фармакологии, кафедра технологии лекарств</p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gurylov</surname><given-names>E. A.</given-names></name><name xml:lang="ru"><surname>Гурылев</surname><given-names>Э. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Pharmacology, Department of Drug Technology</p></bio><bio xml:lang="ru"><p>Кафедра фармакологии, кафедра технологии лекарств</p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Yakupov</surname><given-names>A. G.</given-names></name><name xml:lang="ru"><surname>Якупов</surname><given-names>А. Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Pharmacology, Department of Drug Technology</p></bio><bio xml:lang="ru"><p>Кафедра фармакологии, кафедра технологии лекарств</p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Volkova</surname><given-names>Yu. N.</given-names></name><name xml:lang="ru"><surname>Волкова</surname><given-names>Ю. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Pharmacology, Department of Drug Technology</p></bio><bio xml:lang="ru"><p>Кафедра фармакологии, кафедра технологии лекарств</p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Bulankova</surname><given-names>L. P.</given-names></name><name xml:lang="ru"><surname>Буланкова</surname><given-names>Л. П.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Pharmacology, Department of Drug Technology</p></bio><bio xml:lang="ru"><p>Кафедра фармакологии, кафедра технологии лекарств</p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Lapshina</surname><given-names>S. V.</given-names></name><name xml:lang="ru"><surname>Лапшина</surname><given-names>С. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Pharmacology, Department of Drug Technology</p></bio><bio xml:lang="ru"><p>Кафедра фармакологии, кафедра технологии лекарств</p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Nabiullin</surname><given-names>V. N.</given-names></name><name xml:lang="ru"><surname>Набиуллин</surname><given-names>В. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Pharmacology, Department of Drug Technology</p></bio><bio xml:lang="ru"><p>Кафедра фармакологии, кафедра технологии лекарств</p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shchukina</surname><given-names>L. I.</given-names></name><name xml:lang="ru"><surname>Щукина</surname><given-names>Л. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Pharmacology, Department of Drug Technology</p></bio><bio xml:lang="ru"><p>Кафедра фармакологии, кафедра технологии лекарств</p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kovanova</surname><given-names>E. K.</given-names></name><name xml:lang="ru"><surname>Кованова</surname><given-names>Э. К.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Pharmacology, Department of Drug Technology</p></bio><bio xml:lang="ru"><p>Кафедра фармакологии, кафедра технологии лекарств</p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Kazan Medical University</institution></aff><aff><institution xml:lang="ru">Казанский медицинский университет</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">IOPC named after A. E. Arbuzov Kazan Scientific Center of the Russian Academy of Sciences, JSC "Khiton"</institution></aff><aff><institution xml:lang="ru">ИОФХ им. А. Е. Арбузова КНЦ РАН, АО «Хитон»</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">NPO "Cosmetology" MZMP RF</institution></aff><aff><institution xml:lang="ru">НПО «Косметология» МЗМП РФ</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="1995-05-15" publication-format="electronic"><day>15</day><month>05</month><year>1995</year></pub-date><volume>76</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>201</fpage><lpage>203</lpage><history><date date-type="received" iso-8601-date="2022-02-13"><day>13</day><month>02</month><year>2022</year></date><date date-type="accepted" iso-8601-date="2022-02-13"><day>13</day><month>02</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 1995, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 1995, Эко-Вектор</copyright-statement><copyright-year>1995</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://kazanmedjournal.ru/kazanmedj/article/view/100637">https://kazanmedjournal.ru/kazanmedj/article/view/100637</self-uri><abstract xml:lang="en"><p>The spray lotion «Debut» — a medicinal and cosmetic composition with dimephosphone is developed. It exhibits an antiphlogistic and antiallergic effect and exerts no general toxic effect when used locally. The lotion is effective in skin care which is apt to develop inflammation, irritation, desquamation and acneform eruptions and in therapy of small skin injuries.</p></abstract><trans-abstract xml:lang="ru"><p>Лекарственный препарат димефосфон недавно разрешен к применению по новым медицинским показаниям [2], в том числе как наружное средство в форме 15% водного раствора для лечения ран, рожистого воспаления, угревой болезни, жирной себореи, розовых угрей и др. Присущие димефосфону противовоспалительный, противоаллергический, антисептический, стимулирующий регенерацию и повышающий барьерно-защитные функции кожи и другие эффекты позволяют использовать его в различных лечебно-косметических целях. Однако единственная выпускаемая фармацевтической промышленностью лекарственная форма в виде водного раствора димефосфона, удобная для приема внутрь, не является оптимальной для местного применения.</p></trans-abstract><kwd-group xml:lang="en"><kwd>Kazan Medical archive</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>Казанский медицинский архив</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Инструкция по экспериментально-клинической апробации косметических средств — М., 1986</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Инструкция по применению димефосфона.— М., 1993</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Фержтек О. Косметика и дерматология: Пер. с чешск.— М., 1990</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Хаджай Я. И., Оболенцева Г. 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