THE ROLE OF NEUROHUMORAL IMBALANCE AT POST-TRAUMATIC STRESS DISORDER IN THE ANTITUMOR IMMUNE RESPONSE. EXPERIMENTAL STUDY
| Dublin Core | PKP Metadata Items | Metadata for this Document | |
| 1. | Title | Title of document | THE ROLE OF NEUROHUMORAL IMBALANCE AT POST-TRAUMATIC STRESS DISORDER IN THE ANTITUMOR IMMUNE RESPONSE. EXPERIMENTAL STUDY |
| 2. | Creator | Author's name, affiliation, country | M. V. Kondashevskaya; Avtsyn Research Institute of human morphology of Federal State Budgetary Scientific Institution “Petrovsky National Research Centre of surgery” |
| 2. | Creator | Author's name, affiliation, country | K. A. Artemieva; Avtsyn Research Institute of human morphology of Federal State Budgetary Scientific Institution “Petrovsky National Research Centre of surgery” |
| 2. | Creator | Author's name, affiliation, country | V. V. Aleksankina; Avtsyn Research Institute of human morphology of Federal State Budgetary Scientific Institution “Petrovsky National Research Centre of surgery” |
| 2. | Creator | Author's name, affiliation, country | V. V. Kudelkina; Avtsyn Research Institute of human morphology of Federal State Budgetary Scientific Institution “Petrovsky National Research Centre of surgery” |
| 2. | Creator | Author's name, affiliation, country | A. M. Kosyreva; Avtsyn Research Institute of human morphology of Federal State Budgetary Scientific Institution “Petrovsky National Research Centre of surgery” |
| 2. | Creator | Author's name, affiliation, country | D. A. Areshidze; Avtsyn Research Institute of human morphology of Federal State Budgetary Scientific Institution “Petrovsky National Research Centre of surgery” |
| 2. | Creator | Author's name, affiliation, country | M. A. Kozlova; Avtsyn Research Institute of human morphology of Federal State Budgetary Scientific Institution “Petrovsky National Research Centre of surgery” |
| 2. | Creator | Author's name, affiliation, country | L. M. Mikhaleva; Avtsyn Research Institute of human morphology of Federal State Budgetary Scientific Institution “Petrovsky National Research Centre of surgery” |
| 3. | Subject | Discipline(s) | |
| 3. | Subject | Keyword(s) | mice; В16 melanoma; post-traumatic stress disorder; interleukins; corticosterone |
| 4. | Description | Abstract | The aim of the study was to investigate the growth and development of B16 melanoma in mature male C57Black/6 mice with a post-traumatic stress disorder (PTSD) model. Behavioral, immunohistochemical, morphometric methods, enzyme immunoassay were used. A forced decrease in the level of corticosterone, which is characteristic for PTSD, was established, followed by an intensification of the production of increased concentrations of pro-inflammatory interleukins by the cells of the immune system and, at the same time, a decrease in the secretion of anti-inflammatory cytokines. Priority data were obtained: the neurohumoral imbalance that develops in PTSD is a limiting factor to the growth of B16 melanoma, at least at the initial stages of the oncological process. |
| 5. | Publisher | Organizing agency, location | The Russian Academy of Sciences |
| 6. | Contributor | Sponsor(s) | |
| 7. | Date | (DD-MM-YYYY) | 01.07.2023 |
| 8. | Type | Status & genre | Peer-reviewed Article |
| 8. | Type | Type | |
| 9. | Format | File format | |
| 10. | Identifier | Uniform Resource Identifier | https://kazanmedjournal.ru/2686-7389/article/view/651083 |
| 10. | Identifier | Digital Object Identifier (DOI) | 10.31857/S2686738923600127 |
| 10. | Identifier | eLIBRARY Document Number (EDN) | IYYKGS |
| 11. | Source | Title; vol., no. (year) | Doklady Rossijskoj akademii nauk. Nauki o žizni; Vol 511, No 1 (2023) |
| 12. | Language | English=en | |
| 13. | Relation | Supp. Files |
(64KB) (2MB) (22KB) |
| 14. | Coverage | Geo-spatial location, chronological period, research sample (gender, age, etc.) | |
| 15. | Rights | Copyright and permissions |
Copyright (c) 2023 М.В. Кондашевская, К.А. Артемьева, В.В. Алексанкина, В.В. Куделькина, А.М. Косырева, Д.А. Арешидзе, М.А. Козлова, Л.М. Михалева |