ACUTE TOXICITY OF CERIUM DIOXIDE NANOPARTICLES

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Abstract

The resorptive effects of 0.01 M cerium nanodioxide sol upon single intraperitoneal administration to rats have been studied. The acute exposure to nanoparticles was found to have a dose-dependent general toxic effect on the body (weight loss, inflammatory changes in the abdominal organs, modification of individual behavior, hematological changes, metabolic imbalance), which develops on the background of POL activation. The prooxidant effect of cerium dioxide nanoparticles is demonstratively manifested at relatively high exposure levels (80–8 mg / kg). The threshold dose for the general toxic effect (Limch integr) is equal to 0.8 mg / kg.

About the authors

N. V. Khodykina

Research Institute for Hygiene, Toxicology and Occupational Pathology, Federal Medical and Biological Agency

Author for correspondence.
Email: hodykina@rihtop.ru

Khodykina Nina Vladimirovna

400048, Volgograd

Russian Federation

L. P. Tochilkina

Research Institute for Hygiene, Toxicology and Occupational Pathology, Federal Medical and Biological Agency

Email: tochilkina@rihtop.ru

Tochilkina Lyudmila Petrovna

400048, Volgograd

Russian Federation

O. N. Novikova

Research Institute for Hygiene, Toxicology and Occupational Pathology, Federal Medical and Biological Agency

Email: novikova@rihtop.ru

Novikova Olga Nikolaevna

400048, Volgograd

Russian Federation

M. S. Sroslov

Research Institute for Hygiene, Toxicology and Occupational Pathology, Federal Medical and Biological Agency

Email: SroslovMS@gmail.com

Sroslov Mikhail Sergeyevich

400048, Volgograd

Russian Federation

A. Ya. Pocheptsov

Research Institute for Hygiene, Toxicology and Occupational Pathology, Federal Medical and Biological Agency

Email: pochepcov@rihtop.ru

Pocheptsov Alexander Yakovlevich

400048, Volgograd

Russian Federation

Yu. I. Velikorodnaya

Research Institute for Hygiene, Toxicology and Occupational Pathology, Federal Medical and Biological Agency

Email: velikorodnaya@rihtop.ru

Velikorodnaya Julia Ivanovna

400048, Volgograd

Russian Federation

References

  1. Sejfulla R.D., Rozhkova E.A., Kim E.K. Antioxidants. Experimental and clinical pharmacology. 2009; 72(3):60-64 (in Russian).
  2. Sejfulla R.D. Nanoantioxidants, «Sam poligrafist», 20– 132 p. (in Russian).
  3. Ivanov V.K., Ivanova O.S., Baranchikov A.E., Tret’jakov Ju.D. Cerium Nanocrystalline Dioxide − Component of Effective Antioxidant Preparations. Avaible at: http://www.igic.ras.ru/docs/patent/placat/ionh-3.pdf (Accessed 5 March 2019) (in Russian).
  4. Popov A.L. Investigation of the biological activity of citrate-stabilized cerium dioxide nanoparticles (CeO2): diss. kand. biol. science: 03.01.02 / Popov A. L.; [Place of defense: Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences, 20– 144 p. (in Russian).
  5. Puja Khanna, Cynthia Ong, Boon Huat Bay, Gyeong Hun Baeg. Nanotoxicity: An Interplay of Oxidative Stress, Inflammation and Cell Death: Review. Nanomaterials. 2015; 5:1163-1180; doi: 10.3390/nano5031163.
  6. Geetha N., Prabhavathi G., Ayeshamariam A., Beevi A.H., Punithavelan N., Uthiram C. et al. Review on a Nanomaterials Mechanisms-Induced Oxidative Stress and Toxicity: Review. J Powder Metall. Min. 2017; 6(3):1doi: 10.4172/2168-9806.1000185.
  7. Zuberek M., Grzelak A. NanoparticlesCaused Oxidative Imbalance. Adv. Exp. Med. Biol. 2018; 1048: 691-6doi: 10.1007/9783-319-72041-8_6.
  8. Shherbakov A.B., Ivanova O.S., Spivak N.Ja., Kozik V.V., Ivanov V.K. Synthesis and biomedical applications of nano-dispersed cerium dioxide. – Tomsk, Publishing House of Tomsk State University. – 20– 474 p. (in Russian).
  9. Jawahar Natarajan, Sukumar Nagavishwakya. Nanoceria: A Novel Cytoprotective Drug Delivery Carrier. Current Nanomedicine. 2017; 7(2): 111-1 doi: 10.2174/2468187307666170208104644.
  10. Syed Tawab Shah, Wageeh A. Yehye, Omar Saad, Khanom Simarani, Zaira Zaman Chowdhury, Abeer A.et al. Surface Functionalization of Iron Oxide Nanoparticles with Gallic Acid as Potential Antioxidant and Antimicrobial Agents. Nanomaterials (Basel). 2017 Oct.; 7(10): 3 doi: 10.3390/nano7100306.
  11. Sharpe E., Andreescu D., Andreescu S. Artificial Nanoparticle Antioxidants. Oxidative Stress: Diagnostics, Prevention, and Therapy: Book. 2011; Chapter – P. 235–253.
  12. Gagnon J., Fromm K.M. Toxicity and protective effects of cerium oxide nanoparticles (nanoceria) depending on their preparation method, particle size, cell type, and exposure route. European Journal of Inorganic Chemistry. 2015; (27):4510–4517.
  13. Sanjay, S. Cerium oxide based nanozymes: Redox phenomenon at biointerfaces. Biointerphases. 2016; 11(4): 04B202.
  14. Changyan Li, Xiangcheng Shi, Qiudi Shen, Chen Guo, Zepeng Hou, Jun Zhang. Hot Topics and Challenges of Regenerative Nanoceria in Application of Antioxidant Therapy: Review Article. Journal of Nanomaterials. Volume 20– Article ID 4857461, 12 p.
  15. Sroslov M.S., Tochilkina L.P., Filatov B.N., Hodykina N.V. Experimental study of the acute toxicity of cerium dioxide nanoparticles. In: Nanotoxicology: achievements, problems and prospects: Materials of the scientific conference. Volgograd, 2014; 58-9 (in Russian).
  16. Ranjbar A., Ghasemi H., Kheiripour N. Cerium oxide nanoparticle modulates hepatic damage, inflammatory and oxidative stress biomarkers in a dose-dependent manner: an in vivo study of rat liver. Nanomedicine Journal. 2018; 5(4): 245-250.
  17. Hardas S.S., Sultana S., Warrier G., Dan M., Florence R. L., Wu P. et al.. Rat brain prooxidant effects of peripherally administered 5 nm ceria 30 days after exposure. NeuroToxicology. 2012; 33:1147–1155.
  18. Rzigalinski B. A., Carfagna C. S., Ehrich M. Cerium Oxide Nanoparticles in Neuroprotection and Considerations for Efficacy and Safety. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2017; 9(4): 10.1002/wnan.1444.
  19. Hirst S.M., Karakoti A., Singh S., Self W., Tyler R., Seal S. et al. Bio-distribution and in vivo antioxidant effects of cerium oxide nanoparticles in mice. Environ Toxicol. 2013; 28 (2): 107-118.
  20. Nelson B. C., Johnson M. E., Walker M. L., Riley K. R., Sims Ch. M. Antioxidant Cerium Oxide Nanoparticles in Biology and Medicine: Review. Antioxidants. 2016; 5(15); doi: 10.3390/antiox5020015.

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Copyright (c) 2019 Khodykina N.V., Tochilkina L.P., Novikova O.N., Sroslov M.S., Pocheptsov A.Y., Velikorodnaya Y.I.


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