HMOX1 GENE EXPRESSION IN THE LIVER OF RATS WITH EXPERIMENTAL TETRACHLOROMETHANE HEPATITIS AND ITS CHANGE UNDER THE INFLUENCE OF HEPATOPROTECTORS

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The article presents the comparative effect of hepatoprotective drugs (heptral, mexidol and methyluracil) on the expression of the HMOX1 gene in toxic liver damage induced by carbon tetrachloride (CCl4). Studies were performed on 70 male white outbred rats. Changes in the expression of the HMOX1 gene were more pronounced 72 hours after administration of CCl 4. However, under the influence of drugs, changes in expression multiplicity were most marked after 24 hours. The expression of the HMOX1 gene increased in response to all these treatments. The most pronounced response was obtained with the use of oxymethyluracil. Thus, under the toxic action of CCl4 hepatoprotective drugs enhanced protective and adaptive mechanisms, inducing the activity and expression of the HMOX1 gene.

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G. Mukhammadieva

Ufa Research Institute of Occupational Health and Human Ecology

编辑信件的主要联系方式.
Email: ufniimt@mail.ru
450106, Ufa 俄罗斯联邦

D. Karimov

Ufa Research Institute of Occupational Health and Human Ecology

Email: karimovdo@gmail.com
450106, Ufa 俄罗斯联邦

A. Bakirov

Ufa Research Institute of Occupational Health and Human Ecology

Email: fbun@uniimtech.ru
450106, Ufa 俄罗斯联邦

T. Kutlina

Ufa Research Institute of Occupational Health and Human Ecology

Email: tanya.kutlina.92@mail.ru
450106, Ufa 俄罗斯联邦

Ya. Valova

Ufa Research Institute of Occupational Health and Human Ecology

Email: Q.juk@yandex.ru
450106, Ufa 俄罗斯联邦

E. Kudoyarov

Ufa Research Institute of Occupational Health and Human Ecology

Email: e.kudoyarov@yandex.ru
450106, Ufa 俄罗斯联邦

N. Khusnutdinova

Ufa Research Institute of Occupational Health and Human Ecology

Email: h-n-yu@yandex.ru
450106, Ufa 俄罗斯联邦

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版权所有 © Mukhammadieva G.F., Karimov D.O., Bakirov A.B., Kutlina T.G., Valova Y.V., Kudoyarov E.R., Khusnutdinova N.Y., 2019


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