Koordinacionnaâ himiâ, Vol 50, No 11 (2024)

Coordination Compounds of 3d Metals with 2,4-Dimethylpyrazolo[1,5-а]benzimidazole: Magnetic and Biological Properties

Shakirova O.G., Kuz’menko T.A., Kurat’eva N.V., Klyushova L.S., Lavrov A.N., Lavrenova L.G.

Abstract


New coordination compounds of copper(I), copper(II), cobalt(II), and nickel(II) with 2,4-dimethylpyrazolo[1,5-а]benzimidazole (L) were synthesized and studied. The complexes [CuLCl] (I), [CuLBr] (II), [CuL2Cl2] (III), [CuL2(NO3)2] · H2O (IV), [CoL2Cl2] · 0,5H2O (V), [CoL2(NO3)2] · · 0,5H2O (VI), and [NiL2(NO3)2] · 0,5H2O (VII) were studied by IR spectroscopy and powder and single crystal X-ray diffraction (CCDC nos. 2321779 ([CuL2Cl2]), 2321780 ([CoL2(NO3)2])). The results indicate that the coordination polyhedron in 2,4-dimethylpyrazolo[1,5-a]benzimidazole complexes is formed by the nitrogen atoms of the monodentate ligand and the coordinated anion. The cytotoxic and cytostatic properties of L and complexes I–III were studied in relation to the HepG2 hepatocellular carcinoma cells.