БЕСКОНТАКТНАЯ АТОМНО-СИЛОВАЯ МИКРОСКОПИЯ ДЛЯ ИССЛЕДОВАНИЯ БИОМОЛЕКУЛ В ЖИДКОСТИ

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Аннотация

Бесконтактная атомно-силовая микроскопия, разновидность сканирующей зондовой микроскопии, в последние два десятилетия активно используется для изучения гидратированных биомолекул. В частности, как показывает анализ современной литературы, она является весьма перспективной в исследовании адсорбированных биомакромолекул и биомакромолекулярных комплексов на границе раздела фаз или на поверхности мембран. В настоящем мини-обзоре описываются основы данного метода, его применение для биомолекул, обсуждаются требования к методу и возможности его расширения за счет дополнительной обработки полученных экспериментальных данных с помощью теоретического анализа, молекулярного моделирования или машинного обучения.

Об авторах

Т. Мамедов

Институт теоретической и экспериментальной биофизики РАН

Пущино, Россия

А. Швирст

Институт теоретической и экспериментальной биофизики РАН

Пущино, Россия

М. В Федотова

Институт химии растворов им. Г.А. Крестова РАН

Иваново, Россия

Г. Н Чуев

Институт теоретической и экспериментальной биофизики РАН

Email: genchuev@rambler.ru
Пущино, Россия

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